A3 adenosine receptor activation mechanisms: molecular dynamics analysis of inactive, active, and fully active states
نویسندگان
چکیده
منابع مشابه
Dynamic Behavior of the Active and Inactive States of the Adenosine A2A Receptor
The adenosine A2A receptor (A2AR) belongs to the superfamily of membrane proteins called the G-protein-coupled receptors (GPCRs) that form one of the largest superfamilies of drug targets. Deriving thermostable mutants has been one of the strategies used for crystallization of A2AR in both the agonist and antagonist bound conformational states. The crystal structures do not reveal differences i...
متن کاملComparison of Quality of Life between Active and Inactive Workers
Introduction: Numerous important factors such as physical and mental condition affect the quality of life Job stress is one of the key factors in decreasing productivity in organizations. Given the positive effects of physical activity on quality of life, this study aimed to compare the quality of life between active and inactive workers (case study). Methods: This study was a cross-sectional ...
متن کاملMolecular cloning and characterization of the human A3 adenosine receptor.
The human A3 adenosine receptor was cloned from a striatal cDNA library using a probe derived from the homologous rat sequence. The cDNA encodes a protein of 318 amino acids and exhibits 72% and 85% overall identity with the rat and sheep A3 adenosine receptor sequences, respectively. Specific and saturable binding of the adenosine receptor agonist N6-(4-amino-3-[125I]iodobenzyl)adenosine [125I...
متن کاملConformations of the active and inactive states of opsin.
The signaling state metarhodopsin II of the visual pigment rhodopsin decays to the apoprotein opsin and all-trans retinal, which are then regenerated to rhodopsin by the visual cycle. Opsin is known to have at neutral pH only a small residual constitutive activity toward its G protein transducin, which is thought to play a considerable role in light adaptation (bleaching desensitization). In th...
متن کاملAdenosine A3 Receptor and Cardioprotection
Ischemic injury to the myocardium is a leading cause of morbidity and mortality around the globe.1 It is worth remembering, however, that this insult to the heart emerged only in the last few centuries, an instant in time from an evolutionary perspective. Thus, any cardioprotective responses to ischemic injury undoubtedly evolved for an entirely different purpose. Beyond pure academic interest,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Computer-Aided Molecular Design
سال: 2019
ISSN: 0920-654X,1573-4951
DOI: 10.1007/s10822-019-00246-4